Eosinophilic esophagitis after induction of oral tolerance for cow’s milk proteins

Background The incidence of confirmed cow ́s milk protein (CMP) allergy in infancy is about 2-5% in developed countries. Until now, management strategies included only avoiding CMP intake, because no treatment was available. However, new therapeutic strategies have emerged in the last years. The most important is the induction of oral tolerance (IOT), with results which are promising, improving the quality of life, above all in those who can suffer a severe allergic reaction. Nevertheless, more studies about long-term effects are needed. We describe 4 cases of eosinophilic esophagitis (EoE) after IOT.